![]() Types of drugs that are known to interact with trazodone include:īlood thinners: Blood thinners are medications taken orally or intravenously (through a vein) to prevent a blood clot. The common side effects of this drug include: Headache, muscle ache nausea, vomiting, loss of appetite, or stomachache, constipation or diarrhea, loss of interest in sex (erectile dysfunction in men), dizziness or loss of balance, dry mouth or dry eyes, burning, or tingling sensations and numbness. What are the Common side effects of Pliva 433? Using Pliva 433 for sleep is even more helpful when someone has insomnia or sleep disorders because of depression, although it can also be used as a sleep aid in people without depression. Technically, Pliva 433 is an antidepressant, but it is also frequently used to help people with sleep disorders. Pliva 433 (Trazodone) may also be used in the management of conditions such as cocaine withdrawal, alcohol withdrawal and prevention of migraine ![]() It was approved by FDA in 1981 to be used in the treatment, control and prevention of various medical conditions such as depression, mood disorders, mental health issues, insomnia and other conditions. If you take it once a day, it’s best to take it in the evening or before you go to bed. ![]() Generally, it can take 1 to 2 weeks before trazodone starts to work, but may be 4 to 6 weeks before you feel the full benefit. Pliva 433 can take a while before its impact is felt. How long does Pliva 433 Pill take to kick in? It is chemically similar to nefazodone (Serzone) and shares its actions. Trazodone is chemically unrelated to the selective serotonin reuptake inhibitors (SSRIs), the tricyclic antidepressants (TCAs) or the monoamine oxidase inhibitors (MAO inhibitors). Trazodone may also increase directly the action of serotonin. This results in more serotonin to stimulate other nerves. Although the exact mechanism of action of Pliva 433 is unknown, it probably improves symptoms of depression by inhibiting the uptake of serotonin by nerves inside brain. Many experts believe that an imbalance among the different neurotransmitters is the principal cause of depression. The major neurotransmitters are acetylcholine, norepinephrine, dopamine and serotonin.
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